Pillar Number Seven Of Successful Weight Loss

Restore Healthy Adipocyte Signaling by Life Extension

According to, the author, William Faloon, the adipocyte (fat cell) is the primary site for fat storage.  Adipocytes of obese individuals are bloated with triglycerides, which is the form that most fat exists in the body. Fat storage and release is tightly regulated by adipocyte command signals.

Weight gain occurs when adipocytes (fat cells) enlarge with large amounts of triglycerides. Adipocytes accumulate excess triglycerides due to overeating, nutrient deficiencies, excessive stress, and other causes. These factors, however, fail to address the reason why aging individuals put on fat pounds despite eating less, taking dietary supplements, and following other practices that should in theory lead to weight loss

The aging process adversely affects the adipocyte command signal network, which helps explain the difficulty maturing individuals have in controlling their weight.

Adipocytes regulate their size and number by secreting command signals. The three command signals that regulate adipocytes are:

  • Leptin
  • Adiponectin
  • Glycerol-3-phosphate dehydrogenase.

A West African medicinal food called Irvingia gabonensis has been shown to favorably affect the three adipocyte command centers in the following ways:


Released by adipocytes, leptin travels to the brain to perform two critical functions. First it signals the brain that enough food has been ingested and shuts down appetite.  It then depletes bloated adipocytes by promoting the burning of stored triglycerides.  Leptin is much more abundant in the blood of obese individuals, yet leptin functions to turn off appetite while promoting the burning of triglycerides that bloat our adipocytes.  The reason why obese people have higher blood levels of leptin is that leptin receptor sites on cell membranes are inactivated by inflammatory factors in the body. Irvingia helps unblock “leptin resistance”.


The second command signal released by adipocytes is adiponectin.  The transcription factors associated with adiponectin help determine the amount of triglycerides stored in adipocytes and number of adipocytes formed in the body.  Higher levels of adiponectin enhance insulin sensitivity, which is a long established method to induce weight loss. Gene transcriptional factors involved with adiponectin are directly involved in sequential expression of adipocyte-specific proteins.  Irvingia suppresses transcriptional factors involved in the formation of new adipocytes, while enhancing cell membrane insulin sensitivity by increasing adiponectin.  High circulating levels of adiponectin have been shown to protect against coronary artery disease, whereas low adiponectin levels are observed in overweight individuals.



An enzyme that facilitates the conversion of blood glucose into stored triglyceride fat is glycerol-3-phosphate dehydrogenase.  The presence of this enzyme in the body reveals why low-fat diets alone fail to achieve sustained weight loss, i.e. the body will take ingested carbohydrates and convert them into stored triglyceride fat via the glycerol-3-phosphate dehydrogenase enzyme.  Irvingia inhibits glycerol-3-phosphate dehydrogenase, thus reducing the amount of ingested sugars that are converted to body fat.

Clinical studies have demonstrated significant belly fat and total weight loss in response to taking a 150 mg Irvingia gabonensis extract twice daily. A mechanism for this weight loss reported by many Irvingia users is a reduction in appetite with a concomitant decrease in the number of ingested calories.

If you have any questions on the scientific content of this article, please call a Life Extension Health Advisor at 1-800-226-2370 or visit their website:


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