Pillar Number One Of Successful Weight Loss

Restore Insulin Sensitivity by Life Extension Fundation

According to William Faloon, normal aging causes the insulin receptors on cell membranes to lose their youthful sensitivity or functionality. The result is a pathological condition called insulin resistance that impairs the ability of cells to efficiently take up glucose and utilize it for energy production. Glucose not taken up by energy-producing cells prompts the release of excess insulin.  Hyperinsulinemia, a condition of high circulating insulin levels, is associated with a significantly increased risk of heart disease. In fact, a recent study showed that patients with heart disease had significantly higher plasma levels of blood sugar and circulating insulin.


There are several ways to restore insulin sensitivity to our cell membranes.  For example, nutrients such as chromium, magnesium, cocoa polyphenols, and fish oil can help.

A low-cost prescription drug called metformin can also significantly enhance insulin sensitivity.  It is approved only as a treatment for type 2 diabetes, but published scientific studies indicate it can help reduce body fat.  The dose range for those seeking to enhance their insulin sensitivity and reduce body weight can vary from 250 mg three times daily with meals up to 850 mg three times daily with meals.  Consult with your prescribing physician to make sure that metformin is right for you. As you will read later in this section, restoring free testosterone to youthful ranges markedly enhances insulin sensi-tivity in aging men.

The absolute most effective way of restoring insulin sensitivity is to reduce calorie intake. Calorie restriction to under 1,500-1,800 calories/day significantly enhances insulin sensitivity, as documented by dramatic lowering of fasting glucose and insulin blood levels. Even a moderate cutback of excess calories can markedly improve insulin sensitivity.

So the first pillar to successful long-term weight loss should involve a moderate reduction in calorie intake, at least long enough to restore insulin receptor sensitivity to more youthful ranges.  The use of nutrients, hormones, and drugs that enhance insulin sensitivity should also be considered. As you probably know already, a lot more than just eating less is needed to lose weight.  Hire a good personal trainer/nutrition consultant can keep you motivated.

For more informations, you can contact me.  I work in Palm Beach, West Palm Beach, and Palm Beach Gardens.

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